Forest plot
Early efficacy
Pilot/feasibility
Development
Definitive
Square size ∝ weight; dashed line = 95% prediction interval
Stage-stratified pooled estimates
The methodological contribution of this platform: pooled estimates stratified by trial maturity. Pilot and feasibility studies are separated from early-efficacy evidence.
Study details
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Study locations
Dot size reflects study count. Colour reflects dominant trial stage. The evidence base is heavily concentrated in the USA and UK.